I bought a Ruger LC9 for my wife as her carry weapon, and it fits my hand very well despite that fact that I'm kind of an ogre. It's a touch bigger than the LCP, we got it because it has a slide safety which I think is important for a purse gun.
I CC my M9, if thats any indication of relative size.
My wife has the bodyguard and I carry the LCP on occasion. We use the smaller .380's for when our clothing doesn't allow for a holster on our waistbands. It super easy to just grab the LCP off the dresser and put it in our pocket when running out for something quick. I figure the small .380s are better than carrying nothing.
Me personally carry the LCP because it doesn't have the manual thumb safety. When carrying a gun it should be in a holster (period). I don't like having to worry about the thumb safe when micro seconds matter. Think of the close range that you would be in during a unfortunate event that you would need to use the gun. I am also not an advocate of purse guns either for a couple of reasons, #1 the bad guy is going to grab the purse first, #2 its very hard to draw a gun out of the holster while its in purse. #3 how often is that purse set down somewhere, like in a shopping cart, on the stand at the register, on the floor of the bathroom stall on the table while eating and etc. I would much rather be in total control of my gun at all times.
If your wife chooses to carry in a purse please make sure she keeps the firearm in a holster in a dedicated pocket in her purse which has NOTHING else in it besides the firearm and the holster.
Back to the thumb safe, each person needs to make their own decision on what they feel. There is no right or wrong answer to the question, its all about personal feelings. Just make sure you train correctly for whatever decision you chose. I hear all too often I have a thumb safe, but I keep it off when carrying. That is all said and good, but you should ALWAYS click the thumb safe off and never assume its off because that one time you need the gun and go to fire it, you know that thumb safe will have accidentally get clicked on. So just get in the habbit of always clicking off the thumb safe when you draw the firearm from the holster.
Also about those close combat firearms, I don't worry too much about comfort or how accurate your bullseye is. As long as you can put two or three rounds in the size of a paper plate at 1 to 5 yards you will be good. Its not a range toy.